Living beings can be viewed as a collective, but can also be viewed as individuals. The same can be said of both mortals and cultivators.
Take, for example, mortals. Mortals had souls in their bodies, as well as physical meridians that formed a self-contained network designed to keep out harmful outside influences. That, in turn, helped to prevent illnesses and other mortal dangers.
Cultivators were similar. They had bodies bolstered by spirit energy, and the cycles and operations of their bodies were governed by various natural rules. Depending on the cultivation base and life level of a cultivator, their cycles and operations would reach increasing levels of perfection. After reaching a certain point, it would be virtually impossible for another person to find weaknesses to exploit, and the cultivator’s defenses would be able to resist all outside forces. The only way to kill a cultivator like that was to be far stronger than them, and wipe them out quickly and decisively. But a cultivator with a similar cultivation base would need some special method to defeat them.
That was one of the reasons why immortal skills had been created to begin with. Generally speaking, immortal skills were designed to be gruish and extraordinary. They were supposed to be used to get past an opponent’s defenses with the goal of killing them decisively.
Meanwhile, human nature was complicated and incorporeal. And that meant that it was one of the main targets that many immortal skills would hone in on as a weakness.